Reference SummaryTakeda T, Mech Ageing Dev 1981 Oct;17(2):183-94
Title |
A new murine model of accelerated senescence. |
Authors |
Takeda T; Hosokawa M; Takeshita S; Irino M; Higuchi K; Matsushita T; Tomita Y; Yasuhira K; Hamamoto H; Shimizu K; Ishii M; Yamamuro T |
Journal |
Mech Ageing Dev |
Volume |
17 |
Issue |
2 |
Year |
1981 |
Pages |
183-94 |
Abstract |
Five senescence-prone series of mice (P-1, P-2, P-3, P-4 and P-5) and three senescence-resistant series (R-1, R-2 and R-3) were obtained by continuous sister-brother breeding from five original litters of AKR mice with severe deterioration, and the three original litters of AKR mice with normal aging, respectively. A grading score system was adopted to evaluate the degree of senescence of these mice and a steady and irreversible increase in this grading score was seen with advancing age in both the R and P series. The high grading score in the P series was due to an earlier onset of loss of passivity and reactivity, loss of skin glossiness and increased coarseness, hair loss, periophthalmic lesions, increased lordokyphosis of the spine and a more marked increase in their severity with advancing age as compared to the R series. Among the P series, P-2 showed a 100% incidence of systemic amyloidosis after 6 months of age and P-3 a 70% incidence of cataract over 16 months of age. The life span in the P series was shortened by about 26% of that of the R series. In view of the evidence obtained from the survivors, the growth rate and Gompertz function, the aging pattern in the P series was considered to be an acceleration of senescence. The P series has been named SAM (Senescence Accelerated Mouse). |
Links |
J:28683 – MGI References 7311623 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| SAMR1 | Leukocyte lymphoma | Leukocyte |
20 |
||
| SAMR2 | Leukocyte lymphoma | Leukocyte |
14 |
||
| SAMR3 | Leukocyte lymphoma | Leukocyte |
5 |
||
| SAMP1 | Leukocyte lymphoma | Leukocyte |
14 |
||
| SAMP2 | Leukocyte lymphoma | Leukocyte |
1.6 |
||
| SAMP3 | Leukocyte lymphoma | Leukocyte |
6.9 |
||
| SAMP4 | Leukocyte lymphoma | Leukocyte |
5.9 |
||
| SAMP5 | Leukocyte lymphoma | Leukocyte |
0 |