Reference SummaryStewart TA, Cell 1984 Oct;38(3):627-37

Title

 Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes.

Authors

 Stewart TA; Pattengale PK; Leder P

Journal

 Cell

Volume

 38

Issue

 3

Year

 1984

Pages

 627-37

Abstract

 We have produced 13 strains of transgenic mice that carry an otherwise normal mouse myc gene in which increasingly larger portions of the myc promoter region have been replaced by a hormonally inducible mouse mammary tumor virus promoter. Although expression of the fusion genes varies among these animals, the female founders of two of these transgenic strains spontaneously developed mammary adenocarcinomas during one of their early pregnancies. Both the tumors and the breast tissue of these founder animals expressed RNA transcripts corresponding to the fusion gene. Furthermore, in the best studied strain, all the available F1 female progeny that inherited the MTV/myc gene also developed mammary adenocarcinomas during their second or third pregnancies. Thus, although it has no obvious effect on the early development of these mice, the constitutionally deregulated myc gene appears to act as a heritable, predisposing factor favoring the accelerated development of a tissue-specific adenocarcinoma.

Links

 J:29013 – MGI References
6488314 – National Library of Medicine/PubMed

Strain Notes

Strain Note
CD-1;B6-Tg(MMTV-Myc)139-1Led The transgene was expressed in testis, lung, brain, and salivary gland. Expression of the transgene was not detected in thymus, pancreas, spleen, kidney, liver, heart, muscle, or preputial gland.
CD-1;B6-Tg(MMTV-Myc)141-3Led The transgene was expressed in salivary gland, intestine, and mammary gland. Expression of the transgene was not detected in thymus, pancreas, spleen, kidney, testis, liver, heart, lung, muscle, brain, or preputial gland.
CD-1;B6-Tg(MMTV-Myc)143-3Led The transgene was expressed in salivary gland. Expression of the transgene was not detected in thymus, pancreas, spleen, kidney, testis, liver, heart, lung, muscle, brain, or preputial gland.
CD-1;B6-Tg(MMTV-Myc)143-5Led Expression of the transgene was not detected in thymus, pancreas, spleen, kidney, testis, liver, heart, lung, muscle, brain, salivary gland, preputial gland, intestine, or mammary gland.
CD-1;B6-Tg(MMTV-Myc)147-6Led The transgene was expressed in salivary gland. Expression of the transgene was not detected in thymus, pancreas, spleen, kidney, testis, liver, heart, lung, muscle, brain, or preputial gland.
CD-1;B6-Tg(MMTV-Myc)147-9aLed The founder mouse that gave rise to this strain carried two insertions of the transgene, which were separated by breeding into lines carrying either TgN(MMTV-cmyc)147-9aLed or TgN(MMTV-cmyc)147-9bLed.
The transgene was expressed in thymus, pancreas, spleen, kidney, testis, liver, lung, muscle, brain, salivary gland, and preputial gland.
CD-1;B6-Tg(MMTV-Myc)147-9bLed The founder mouse that gave rise to this strain carried two insertions of the transgene, which were separated by breeding into lines carrying either TgN(MMTV-cmyc)147-9aLed or TgN(MMTV-cmyc)147-9bLed.
The transgene was expressed in spleen, testis, lung, brain, salivary gland, and preputial gland. Expression of the transgene was not detected in thymus, pancreas, kidney, liver, heart, or muscle.
CD-1;B6-Tg(MMTV-Myc)155-2Led The transgene was expressed in salivary gland. Expression of the transgene was not detected in thymus, pancreas, spleen, kidney, testis, liver, heart, lung, muscle, brain, or preputial gland.
CD-1;B6-Tg(MMTV-Myc)155-7Led The transgene was expressed in salivary gland. Expression of the transgene was not detected in thymus, pancreas, spleen, kidney, testis, liver, heart, lung, muscle, brain, or preputial gland.
CD-1;B6-Tg(MMTV-Myc)164-4Led This founder mouse carried two insertions of the transgene. They were later separated by breeding to give rise to strains carrying either TgN(MMTV-cmyc)164-4aLed or TgN(MMTV-cmyc)164-4bLed.
CD-1;B6-Tg(MMTV-Myc)165-1aLed The founder mouse that gave rise to strains B6;CD-1-TgN(MMTV-cmyc)165-1aLed and B6;CD-1-TgN(MMTV-cmyc)165-1bLed carried a polymorphism at a single locus.
The transgene was expressed in testis and salivary gland. Expression of the transgene was not detected in thymus, pancreas, spleen, kidney, liver, heart, lung, muscle, brain, or preputial gland.
CD-1;B6-Tg(MMTV-Myc)165-1bLed The founder mouse that gave rise to strains B6;CD-1-TgN(MMTV-cmyc)165-1aLed and B6;CD-1-TgN(MMTV-cmyc)165-1bLed carried a polymorphism at a single locus.
The transgene was expressed in testis and salivary gland. Expression of the transgene was not detected in thymus, pancreas, spleen, kidney, liver, heart, lung, muscle, brain, or preputial gland.

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
CD-1;B6-Tg(MMTV-Myc)164-4Led Mammary gland adenocarcinoma Mammary gland

100
CD-1;B6-Tg(MMTV-Myc)141-3Led Mammary gland adenocarcinoma Mammary gland

100
CD-1;B6-Tg(MMTV-Myc)141-3Led Mammary gland dysplasia Mammary gland

100
CD-1;B6-Tg(MMTV-Myc)164-4Led Salivary gland tumor Salivary gland

0
CD-1;B6-Tg(MMTV-Myc)141-3Led Salivary gland tumor Salivary gland

0
CD-1;B6-Tg(MMTV-Myc)155-2Led (Unspecified organ) tumor (Unspecified organ)

0
CD-1;B6-Tg(MMTV-Myc)155-7Led (Unspecified organ) tumor (Unspecified organ)

0
CD-1;B6-Tg(MMTV-Myc)147-6Led (Unspecified organ) tumor (Unspecified organ)

0
CD-1;B6-Tg(MMTV-Myc)147-9aLed (Unspecified organ) tumor (Unspecified organ)

0
CD-1;B6-Tg(MMTV-Myc)147-9bLed (Unspecified organ) tumor (Unspecified organ)

0
CD-1;B6-Tg(MMTV-Myc)139-1Led (Unspecified organ) tumor (Unspecified organ)

0
CD-1;B6-Tg(MMTV-Myc)143-3Led (Unspecified organ) tumor (Unspecified organ)

0
CD-1;B6-Tg(MMTV-Myc)143-5Led (Unspecified organ) tumor (Unspecified organ)

0
CD-1;B6-Tg(MMTV-Myc)165-1aLed (Unspecified organ) tumor (Unspecified organ)

0
CD-1;B6-Tg(MMTV-Myc)165-1bLed (Unspecified organ) tumor (Unspecified organ)

0