Reference SummaryDudley ME, Int J Cancer 1996 Jan 17;65(2):249-53
Title |
Frequency and histological appearance of adenomas in multiple intestinal neoplasia mice are unaffected by severe combined immunodeficiency (scid) mutation. | ||||
Authors |
Dudley ME; Sundberg JP; Roopenian DC | ||||
Journal |
Int J Cancer | ||||
Volume |
65 | ||||
Issue |
2 | ||||
Year |
1996 | ||||
Pages |
249-53 | ||||
Abstract |
Well-characterized murine mutations are powerful analytical tools for the genetic analysis of tumorigenesis. We crossed the multiple intestinal neoplasia (Min) allele of adenomatous polyposis coli (Apc), which produces a profound pre-disposition to intestinal neoplasia, with the severe combined immunodeficiency (scid) mutation, which causes defective double-strand DNA repair and severe immunodeficiency, on the common C57BL/6J genetic background to assay for any combined effect on intestinal tumorigenesis. Several phenotypic traits were exacerbated in an apparently additive manner in the double mutant mice, including reduced immunoglobulin levels, reduced body weight and increased morbidity. However, quantitation and histological evaluation of polyp phenotype indicated that these mutations did not interact to affect either polyp frequency or progression. Thus, neither genome instability nor lack of immunosurveillance conferred by scid contributes to intestinal polyps in this model. | ||||
Links |
J:31690 – MGI References 8567125 – National Library of Medicine/PubMed |
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Strain Notes
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| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C57BL/6J-ApcMin/+ | Intestine - Small Intestine dysplasia | Intestine - Small Intestine |
observed |
||
| C57BL/6J-ApcMin/+ Prkdcscid/SzJ | Intestine - Small Intestine dysplasia | Intestine - Small Intestine |
observed |
||
| C57BL/6J-ApcMin/+ | Intestine - Small Intestine polyp | Intestine - Small Intestine |
very high |
||
| C57BL/6J-ApcMin/+ Prkdcscid/SzJ | Intestine - Small Intestine polyp | Intestine - Small Intestine |
very high |
||
| C57BL/6J-ApcMin/+ | Intestine tumor | Intestine |
100 |
||
| C57BL/6J-ApcMin/+ Prkdcscid/SzJ | Mammary gland adenoacanthoma | Mammary gland |
observed |