Reference SummaryPierre F, Cancer Res 1997 Jan 15;57(2):225-8

Title

Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice.

Authors

Pierre F; Perrin P; Champ M; Bornet F; Meflah K; Menanteau J

Journal

Cancer Res

Volume

Issue

Year

1997

Pages

225-8

Abstract

C57BL/6J-Min/+ mice, which are heterozygous for a non-sense mutation in the Apc gene, provide a model for both familial adenomatous polyposis and sporadic colon cancers. In our study, gut tumors and small intestine lymphoid nodules were counted in Min mice fed fiber-enriched diets for 6 weeks. Neither starch-free wheat bran nor resistant starch modified the number of tumors. However, short-chain fructo-oligosaccharides dramatically reduced the incidence of colon tumors and concomitantly developed gut-associated lymphoid tissue. Our experiment shows that short-chain fructo-oligosaccharides counteract advanced stages of colon carcinogenesis, possibly via stimulation of antitumoral immunity by modulation of the colonic ecosystem.

Links

J:38422 – MGI References
9000559 – National Library of Medicine/PubMed

Strain Notes

Strain	Note
C57BL/6J-Apc^Min/+	These mice were from The Jackson Laboratory.

Models
Strain	Model Name	Treatment Agent(s)	Organ Affected	Frequency
C57BL/6J-Apc^Min/+	Intestine - Large Intestine - Colon tumor	low fiber	Intestine - Large Intestine - Colon	100
C57BL/6J-Apc^Min/+	Intestine - Large Intestine - Colon tumor	high fiber	Intestine - Large Intestine - Colon	60 - 100
C57BL/6J-Apc^Min/+	Intestine - Small Intestine tumor	low fiber	Intestine - Small Intestine	100
C57BL/6J-Apc^Min/+	Intestine - Small Intestine tumor	high fiber	Intestine - Small Intestine	100