Reference SummaryNakatsugi S, Jpn J Cancer Res 1997 Dec;88(12):1117-20

Title

 Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min mice

Authors

 Nakatsugi S; Fukutake M; Takahashi M; Fukuda K; Isoi T; Taniguchi Y; Sugimura T; Wakabayashi K

Journal

 Jpn J Cancer Res

Volume

 88

Issue

 12

Year

 1997

Pages

 1117-20

Abstract

 Nonsteroidal anti-inflammatory drugs (NSAIDs) suppress colon carcinogenesis in man and experimental animals. However, conventional NSAIDs inhibit both cyclooxygenase (COX) isoforms, COX-1 and COX-2, and cause gastrointestinal side-effects. Nimesulide, a selective inhibitor of COX-2, is much less ulcerogenic. We, therefore, examined its influence on the development of intestinal polyps in Min mice. Female Min mice at 4 weeks old were given 400 ppm nimesulide in their diet for 11 weeks. This treatment resulted in a significant reduction of the numbers of both small and large intestinal polyps, the total being 52% of that in untreated control Min mice. The size of the polyps in the nimesulide-treated group was also significantly decreased. The results suggest that nimesulide is a good candidate as a chemopreventive agent for human colon cancer with low toxicity.

Links

 J:45606 – MGI References
9473726 – National Library of Medicine/PubMed

Strain Notes

Strain Note
C57BL/6J-ApcMin/+ Mice were obtained from The Jackson Laboratory at 4 weeks of age.
'Nimesulide treatment caused no significant changes in other organs such as the liver, lung, spleen, and kidney.'

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/6J-ApcMin/+ Intestine - Large Intestine adenoma Intestine - Large Intestine

observed
C57BL/6J-ApcMin/+ Intestine - Large Intestine adenoma
  • nimesulide (4-nitro-2-phenoxymethanesulfonanilide)
 Intestine - Large Intestine

observed
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Distal adenoma Intestine - Small Intestine - Distal

observed
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Distal adenoma
  • nimesulide (4-nitro-2-phenoxymethanesulfonanilide)
 Intestine - Small Intestine - Distal

observed
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Medial adenoma Intestine - Small Intestine - Medial

observed
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Medial adenoma
  • nimesulide (4-nitro-2-phenoxymethanesulfonanilide)
 Intestine - Small Intestine - Medial

observed
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Proximal adenoma Intestine - Small Intestine - Proximal

observed
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Proximal adenoma
  • nimesulide (4-nitro-2-phenoxymethanesulfonanilide)
 Intestine - Small Intestine - Proximal

observed
C57BL/6J-ApcMin/+ Intestine adenoma Intestine

observed
C57BL/6J-ApcMin/+ Intestine adenoma
  • nimesulide (4-nitro-2-phenoxymethanesulfonanilide)
 Intestine

observed