Reference SummaryLeder A, Cell 1986 May 23;45(4):485-95

Title

 Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development.

Authors

 Leder A; Pattengale PK; Kuo A; Stewart TA; Leder P

Journal

 Cell

Volume

 45

Issue

 4

Year

 1986

Pages

 485-95

Abstract

 We have constructed a transgenic mouse strain in which a mammary tumor virus LTR/c-myc fusion gene is anomalously expressed in a wide variety of tissues. The deregulated c-myc transgene, now glucocorticoid inducible, contributes to an increased incidence of a variety of tumors, including those of testicular, breast, lymphocytic (B cell and T cell), and mast cell origin. The deregulated gene does not, however, otherwise disturb cell proliferation, nor does it interfere with normal development in these animals. Moreover, since not all tissues that express the transgene develop neoplasms, these results begin to define the transforming spectrum of the c-myc oncogene. They also extend to several organ systems the notion that elements in addition to an activated c-myc gene are required to induce malignancy in the living organism.

Links

 J:72130 – MGI References
3011271 – National Library of Medicine/PubMed

Strain Notes

Strain Note
CD-1;B6-Tg(MMTV-Myc)147-9bLed Five to ten copies of the transgene were inserted at each integration site.
These mice are homozygous for the transgene.
The transgene was expressed at high levels in the lung, pancreas, and salivary gland.
CD-1;B6-Tg(MMTV-Myc)147-9bLed Five to ten copies of the transgene were inserted at the integration site.
These mice are either hemizygous or homozygous for the transgene.
The transgene was expressed at high levels in the lung, pancreas, and salivary gland.
The transgene was expressed in the mammary gland, salivary gland, spleen, testis, lung, brain, and preputial gland.

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
CD-1;B6-Tg(MMTV-Myc)147-9bLed Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

observed
CD-1;B6 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

1.0
CD-1;B6-Tg(MMTV-Myc)147-9bLed Leukocyte - Lymphocyte - B-lymphocyte lymphoma - immunoblastic Leukocyte - Lymphocyte - B-lymphocyte

8.3
CD-1;B6-Tg(MMTV-Myc)147-9bLed Leukocyte - Lymphocyte - Null (non-T, non-B) cell lymphoma - lymphoblastic Leukocyte - Lymphocyte - Null (non-T, non-B) cell

8.3
CD-1;B6-Tg(MMTV-Myc)147-9bLed Leukocyte - Lymphocyte - Pre-B-lymphocyte lymphoma - lymphoblastic Leukocyte - Lymphocyte - Pre-B-lymphocyte

7.7 - 8.3
CD-1;B6-Tg(MMTV-Myc)147-9bLed Leukocyte - Lymphocyte - T-lymphocyte lymphoma - lymphoblastic Leukocyte - Lymphocyte - T-lymphocyte

8.3
CD-1;B6-Tg(MMTV-Myc)147-9bLed Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell sarcoma - mast cell Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell

7.7 - 8.3
CD-1;B6-Tg(MMTV-Myc)147-9bLed Lung tumor Lung

0
CD-1;B6-Tg(MMTV-Myc)147-9bLed Lung tumor Lung

0
CD-1;B6-Tg(MMTV-Myc)147-9bLed Mammary gland adenocarcinoma Mammary gland

25 - 100
CD-1;B6-Tg(MMTV-Myc)147-9bLed Pancreas tumor Pancreas

0
CD-1;B6-Tg(MMTV-Myc)147-9bLed Pancreas tumor Pancreas

0
CD-1;B6-Tg(MMTV-Myc)147-9bLed Salivary gland tumor Salivary gland

0
CD-1;B6-Tg(MMTV-Myc)147-9bLed Salivary gland tumor Salivary gland

0
CD-1;B6-Tg(MMTV-Myc)147-9bLed Testis - Seminiferous tubule - Sertoli cell tumor Testis - Seminiferous tubule - Sertoli cell

23
CD-1;B6-Tg(MMTV-Myc)147-9bLed Testis - Seminiferous tubule - Sertoli cell tumor Testis - Seminiferous tubule - Sertoli cell

33
CD-1;B6-Tg(MMTV-Myc)147-9bLed (Unspecified organ) tumor (Unspecified organ)

67