Reference SummaryHesselager G, Cancer Res 2003 Aug 1;63(15):4305-9
Title |
Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model. | ||||
Authors |
Hesselager G; Uhrbom L; Westermark B; Nister M | ||||
Journal |
Cancer Res | ||||
Volume |
63 | ||||
Issue |
15 | ||||
Year |
2003 | ||||
Pages |
4305-9 | ||||
Abstract |
INK4a-ARF and p53 inactivation are common but rarely concurrent findings in glioblastoma multiforme. Here we demonstrate that experimental deletion of either tumor suppressor gene cooperates with retrovirally expressed platelet-derived growth factor (PDGF)-B regarding both tumor latency and frequency in a mouse brain tumor model. We find indications of PTEN down-regulation and increased Akt phosphorylation in both types of null tumors (although more prominent in p53-/- tumors) suggesting a possible mechanism for this synergism. This is the first time that the cooperative tumorigenic effects of PDGF-B stimulation and p53 loss of function are demonstrated in an in vivo model, establishing a functional link between two common molecular changes of human secondary glioblastoma multiforme. | ||||
Links |
J:84848 – MGI References 12907595 – National Library of Medicine/PubMed |
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Strain Notes
|
|||||
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| B6;129 | CNS - Brain tumor |
|
CNS - Brain |
56 |
|
| B6;129-Trp53tm1Brd | CNS - Brain tumor |
|
CNS - Brain |
89.47 |
|
| B6;129-Trp53tm1Brd | CNS - Brain tumor |
|
CNS - Brain |
0 |
|
| STOCK | CNS - Brain tumor | CNS - Brain |
60 |
||
| STOCK Cdkn2atm1Rdp | CNS - Brain tumor |
|
CNS - Brain |
83.33 |
|
| STOCK Cdkn2atm1Rdp | CNS - Brain tumor |
|
CNS - Brain |
0 |