Reference SummaryTakeda H, Br J Cancer 2004 Feb 9;90(3):701-4
Title |
Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas. |
Authors |
Takeda H; Miyoshi H; Tamai Y; Oshima M; Taketo MM |
Journal |
Br J Cancer |
Volume |
90 |
Issue |
3 |
Year |
2004 |
Pages |
701-4 |
Abstract |
Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. Here, we demonstrate stromal expression of both COX-2 and microsomal prostaglandin E(2) synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1(+/-), Smad4(+/-) and Cdx2(+/-)mice. These results suggest that PGE(2) produced by COX-2 and mPGES-1 plays an important role in hamartoma development regardless of the mutated genes causing hamartomas.British Journal of Cancer (2004) 90, 701-704. doi:10.1038/sj.bjc.6601584 www.bjcancer.com |
Links |
J:88082 – MGI References 14760387 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| [not specified]-Cdx2tm1Mmt/+ | Intestine - Large Intestine - Colon hamartoma | Intestine - Large Intestine - Colon |
observed |
||
| [not specified]-Smad4tm1Mmt/+ | Stomach hamartoma | Stomach |
observed |
||
| [not specified]-Stk11tm1Mmt/+ | Stomach hamartoma | Stomach |
observed |