Reference SummaryPino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63

Title

 Promotion of Colon Tumors in C57BL/6J-APC(min)/+ Mice by Thiazolidinedione PPARgamma Agonists and a Structurally Unrelated PPARgamma Agonist.

Authors

 Pino MV; Kelley MF; Jayyosi Z

Journal

 Toxicol Pathol

Volume

 32

Issue

 1

Year

 2004

Pages

 58-63

Abstract

 Thiazolidinedione PPARgamma agonists (troglitazone and rosiglitazone) were previously shown to promote colon tumor formation in C57BL/6J-APC(min)/+ mice, a model for human familial adenomatous polyposis. This study was conducted to determine if another thiazolidinedione PPARgamma agonist, pioglitazone, and a PPARgamma agonist structurally unrelated to the thiazolidinedione family, NID525, (a tetrazole-substituted phenoxymethylquinolone), would also promote colon tumors in this mouse model. Mice were treated in-feed with the thiazolidinediones troglitazone (150 mg/kg/day), rosiglitazone (20 mg/kg/day), or pioglitazone (150 mg/kg/day), or with NID525 (150 mg/kg/day) for 8 weeks. An increased incidence in colon tumors compared to controls was observed for all of the thiazolidinedione-treated groups as well as the NID525-treated group. These results indicate that the tumor-promoting effect of PPARgamma agonists in the colon of C57BL/6J-APC(min)/+ mice is likely related to the pharmacological activity of this group of drugs and not the thiazolidinedione structure.

Links

 J:88111 – MGI References
14713549 – National Library of Medicine/PubMed

Strain Notes

Strain Note
C57BL/6J-ApcMin/+ Mice were purchased from The Jackson Laboratory.

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/6J-ApcMin/+ Intestine - Large Intestine adenocarcinoma Intestine - Large Intestine

0
C57BL/6J-ApcMin/+ Intestine - Large Intestine adenocarcinoma
  • NID525, PPAR gamma agonist
 Intestine - Large Intestine

0
C57BL/6J-ApcMin/+ Intestine - Large Intestine adenocarcinoma
  • troglitazone
 Intestine - Large Intestine

6.7
C57BL/6J-ApcMin/+ Intestine - Large Intestine adenocarcinoma
  • pioglitazone
 Intestine - Large Intestine

0
C57BL/6J-ApcMin/+ Intestine - Large Intestine adenocarcinoma
  • rosiglitazone
 Intestine - Large Intestine

0
C57BL/6J-ApcMin/+ Intestine - Large Intestine adenoma Intestine - Large Intestine

60
C57BL/6J-ApcMin/+ Intestine - Large Intestine adenoma
  • NID525, PPAR gamma agonist
 Intestine - Large Intestine

100
C57BL/6J-ApcMin/+ Intestine - Large Intestine adenoma
  • troglitazone
 Intestine - Large Intestine

observed
C57BL/6J-ApcMin/+ Intestine - Large Intestine adenoma
  • pioglitazone
 Intestine - Large Intestine

100
C57BL/6J-ApcMin/+ Intestine - Large Intestine adenoma
  • rosiglitazone
 Intestine - Large Intestine

100
C57BL/6J-ApcMin/+ Intestine - Large Intestine hyperplasia Intestine - Large Intestine

observed
C57BL/6J-ApcMin/+ Intestine - Large Intestine hyperplasia
  • NID525, PPAR gamma agonist
 Intestine - Large Intestine

observed
C57BL/6J-ApcMin/+ Intestine - Large Intestine hyperplasia
  • troglitazone
 Intestine - Large Intestine

observed
C57BL/6J-ApcMin/+ Intestine - Large Intestine hyperplasia
  • pioglitazone
 Intestine - Large Intestine

observed
C57BL/6J-ApcMin/+ Intestine - Large Intestine hyperplasia
  • rosiglitazone
 Intestine - Large Intestine

observed
C57BL/6J-ApcMin/+ Intestine - Large Intestine tumor
  • troglitazone
 Intestine - Large Intestine

93
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Distal adenoma Intestine - Small Intestine - Distal

100
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Distal adenoma
  • NID525, PPAR gamma agonist
 Intestine - Small Intestine - Distal

100
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Distal tumor
  • troglitazone
 Intestine - Small Intestine - Distal

100
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Distal tumor
  • pioglitazone
 Intestine - Small Intestine - Distal

100
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Distal tumor
  • rosiglitazone
 Intestine - Small Intestine - Distal

100
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Proximal adenoma Intestine - Small Intestine - Proximal

100
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Proximal adenoma
  • NID525, PPAR gamma agonist
 Intestine - Small Intestine - Proximal

100
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Proximal tumor
  • troglitazone
 Intestine - Small Intestine - Proximal

100
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Proximal tumor
  • pioglitazone
 Intestine - Small Intestine - Proximal

100
C57BL/6J-ApcMin/+ Intestine - Small Intestine - Proximal tumor
  • rosiglitazone
 Intestine - Small Intestine - Proximal

100