Reference SummaryGupta RA, Nat Med 2004 Mar;10(3):245-7

Title

Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth.

Authors

Gupta RA; Wang D; Katkuri S; Wang H; Dey SK; DuBois RN

Journal

Nat Med

Volume

Issue

Year

2004

Pages

245-7

Abstract

We treated Apc(min) mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-delta (PPAR-delta). Exposure of Apc(min) mice to the PPAR-delta ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-delta in the regulation of intestinal adenoma growth.

Links

J:88127 – MGI References
14758356 – National Library of Medicine/PubMed

Strain Notes

Strain	Note
C57BL/6J-Apc^Min/+	These mice were from The Jackson Laboratory.

Models
Strain	Model Name	Treatment Agent(s)	Organ Affected	Frequency
C57BL/6J-Apc^Min/+	Intestine - Large Intestine - Colon polyp	GW501516, PPAR-delta agonist	Intestine - Large Intestine - Colon	observed
C57BL/6J-Apc^Min/+	Intestine - Large Intestine - Colon polyp		Intestine - Large Intestine - Colon	observed
C57BL/6J-Apc^Min/+	Intestine - Large Intestine polyp		Intestine - Large Intestine	observed
C57BL/6J-Apc^Min/+	Intestine - Small Intestine polyp		Intestine - Small Intestine	observed
C57BL/6J-Apc^Min/+	Intestine - Small Intestine polyp	GW501516, PPAR-delta agonist	Intestine - Small Intestine	observed