Strain SummarySTOCK Cdkn2a^tm1Rdp

Strain Name	STOCK Cdkn2a^tm1Rdp
Strain Type(s)	targeted mutation (knockout)
Strain Synonym(s)	Cdkn2a^-/- • ink4a-deficient • INK4a-deficient • INK4a-null • ink4a^-/- • INK4a^-/- • mxi1^+/+ ink4a^-/-
Description	Homozygous mice. The genetic background of these mice was a mixture of C57BL/6, 129/Sv, and SJL.
Strain Genetics	Mxi1⁺ / Mxi1⁺
	List all models in MMHCdb carrying the Cdkn2a^tm1Rdp allele Cdkn2a^tm1Rdp / Cdkn2a^tm1Rdp

Models
25 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Adipose tissue liposarcoma	Adipose tissue		observed				References: Serrano M, Cell 1996 Apr 5;85(1):27-37
Blood vessel hemangiosarcoma	Blood vessel			observed			References: Serrano M, Cell 1996 Apr 5;85(1):27-37
Connective tissue - Fibroblast fibrosarcoma	Connective tissue - Fibroblast		observed				References: Serrano M, Cell 1996 Apr 5;85(1):27-37
Connective tissue - Fibroblast fibrosarcoma	Connective tissue - Fibroblast	ultraviolet-B radiation (UVB)	observed	observed			References: Serrano M, Cell 1996 Apr 5;85(1):27-37
Connective tissue - Fibroblast fibrosarcoma	Connective tissue - Fibroblast	ultraviolet-B radiation (UVB) ⋅ 9,10-dimethyl-1,2-benzanthracene (DMBA)	observed	observed			References: Serrano M, Cell 1996 Apr 5;85(1):27-37
Leukocyte - Lymphocyte - B-lymphocyte lymphoma	Leukocyte - Lymphocyte - B-lymphocyte	ultraviolet-B radiation (UVB) ⋅ 9,10-dimethyl-1,2-benzanthracene (DMBA)	observed	observed			References: Serrano M, Cell 1996 Apr 5;85(1):27-37
Leukocyte - Lymphocyte - B-lymphocyte lymphoma	Leukocyte - Lymphocyte - B-lymphocyte			observed			References: Serrano M, Cell 1996 Apr 5;85(1):27-37
Leukocyte - Lymphocyte - B-lymphocyte lymphoma	Leukocyte - Lymphocyte - B-lymphocyte	MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV)				12.17	References: Lund AH, Nat Genet 2002 Sep;32(1):160-5
Leukocyte - Lymphocyte - T-lymphocyte lymphoma	Leukocyte - Lymphocyte - T-lymphocyte	MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV)				60	References: Lund AH, Nat Genet 2002 Sep;32(1):160-5
Leukocyte - Lymphocyte lymphoma	Leukocyte - Lymphocyte	MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV)				80	References: Lund AH, Nat Genet 2002 Sep;32(1):160-5
Leukocyte - Lymphocyte lymphoma - mixed	Leukocyte - Lymphocyte	MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV)				7.83	References: Lund AH, Nat Genet 2002 Sep;32(1):160-5
Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma	Leukocyte - Monocyte - Macrophage - Histiocyte	MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV)				54.78	References: Lund AH, Nat Genet 2002 Sep;32(1):160-5
Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma	Liver	MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV)				observed	References: Lund AH, Nat Genet 2002 Sep;32(1):160-5
Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma	Spleen	MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV)				observed	References: Lund AH, Nat Genet 2002 Sep;32(1):160-5
Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma	Leukocyte - Monocyte - Macrophage - Histiocyte					66.67	References: Lund AH, Nat Genet 2002 Sep;32(1):160-5
Leukocyte lymphoma	Leukocyte		observed				References: Serrano M, Cell 1996 Apr 5;85(1):27-37
Leukocyte lymphoma	Leukocyte	ultraviolet-B radiation (UVB)	observed	observed			References: Serrano M, Cell 1996 Apr 5;85(1):27-37
Leukocyte lymphoma	Leukocyte	ultraviolet-B radiation (UVB) ⋅ 9,10-dimethyl-1,2-benzanthracene (DMBA)	observed	observed			References: Serrano M, Cell 1996 Apr 5;85(1):27-37
Mesodermal cell/mesoblast sarcoma	Mesodermal cell/mesoblast		observed				References: Serrano M, Cell 1996 Apr 5;85(1):27-37
Mesodermal cell/mesoblast sarcoma	Mesodermal cell/mesoblast	ultraviolet-B radiation (UVB)		observed			References: Serrano M, Cell 1996 Apr 5;85(1):27-37
Skin - Melanocyte melanoma	Skin - Melanocyte					0	References: Chin L, Genes Dev 1997 Nov 1;11(21):2822-34
Skin squamous cell carcinoma	Skin	ultraviolet-B radiation (UVB)	observed	observed			References: Serrano M, Cell 1996 Apr 5;85(1):27-37
Skin squamous cell carcinoma	Skin	ultraviolet-B radiation (UVB) ⋅ 9,10-dimethyl-1,2-benzanthracene (DMBA)	observed				References: Serrano M, Cell 1996 Apr 5;85(1):27-37
(Unspecified organ) tumor	(Unspecified organ)	9,10-dimethyl-1,2-benzanthracene (DMBA)				20	References: Schreiber-Agus N, Nature 1998 Jun 4;393(6684):483-7
(Unspecified organ) tumor	(Unspecified organ)					100	References: Lund AH, Nat Genet 2002 Sep;32(1):160-5

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Models