Strain SummaryB6;129S1-Cdkn1b^tm1Ako Pten^tm1Ppp/+

Strain Name	B6;129S1-Cdkn1b^tm1Ako Pten^tm1Ppp/+
Strain Type(s)	targeted mutation (knockout)
Strain Synonym(s)	B6;129S1-Pten^tm1Ppp/+ Cdkn1b^tm1Ako • Pten^+/-/Cdkn1b^-/- • Pten^+/-;Cdkn1b^-/-
Description	Double-mutant mice heterozygous for a targeted mutation of Pten, and homozygous for a targeted mutation of Cdkn1b (p27^KIP1). The background was a mix of C57BL/6 and 129S1/Sv.
Strain Genetics	List all models in MMHCdb carrying the Pten^tm1Ppp allele Pten^tm1Ppp / Pten⁺
	List all models in MMHCdb carrying the Cdkn1b^tm1Ako allele Cdkn1b^tm1Ako / Cdkn1b^tm1Ako

Models
9 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Adrenal gland - Medulla tumor	Adrenal gland - Medulla					100	References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4
Intestine - Large Intestine adenocarcinoma	Intestine - Large Intestine					16	References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4
Intestine - Small Intestine - Ileum polyp	Intestine - Small Intestine - Ileum					100	References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4
Intestine - Small Intestine adenocarcinoma	Intestine - Small Intestine					52	References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4
Lung adenocarcinoma	Lung					0	References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4
Prostate gland carcinoma	Prostate gland					25	References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4
Prostate gland prostatic intraepithelial neoplasia (PIN)	Prostate gland					100	References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4
Thyroid gland carcinoma - follicular	Thyroid gland					100	References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4
Uterus - Endometrium hyperplasia	Uterus - Endometrium		100				References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4

Models