Strain SummaryB6;129S4
Strain Name |
B6;129S4 |
Strain Type(s) |
other |
Strain Synonym(s) |
B6,129 • B6;129 • B6,129 (NIH) • C57BL/6 and 129 • wild-type (+/+) |
Description |
The genetic background of these mice was a mixture of C57BL/6NCr and 129S4/SvJae. Wild type controls for targeted mutant mice. |
Strain Genetics |
|
| Frequency | ||||||||
|---|---|---|---|---|---|---|---|---|
| Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
| Adrenal gland - Medulla hyperplasia | Adrenal gland - Medulla |
10 |
0 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla |
2.0 |
0 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Subcapsular cell |
86 |
12 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Blood vessel hemangioma | Liver |
2.0 |
0 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Blood vessel hemangioma | Uterus |
2.0 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
|||||
| Blood vessel hemangiosarcoma | Liver |
0 |
2.0 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Blood vessel neoplasm | Blood vessel |
0 |
0 - 10 |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
||||
| Bone neoplasm | Bone |
0 |
0 |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
||||
| Connective tissue - Fibroblast fibroma | Intestine - Large Intestine - Cecum |
2.2 |
0 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Ear - Middle ear hyperplasia | Ear - Middle ear |
observed |
observed |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Eye - Harderian gland adenoma | Eye - Harderian gland |
4.1 |
4.0 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Eye - Harderian gland neoplasm | Eye - Harderian gland |
0 - 4 |
0 - 4 |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
||||
| Intestine - Small Intestine adenoma | Intestine - Small Intestine |
4.2 |
4.3 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Intestine neoplasm | Intestine |
4 |
4 |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
||||
| Kidney cyst | Kidney |
8.3 |
44 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Leukocyte - Lymphoblast lymphoma - lymphoblastic | Leukocyte - Lymphoblast |
0 |
4.0 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma | Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell |
65 |
38 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Leukocyte - Lymphocyte - B-lymphocyte hyperplasia - splenic marginal zone | Spleen |
4.2 |
0 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Leukocyte - Lymphocyte - B-lymphocyte lymphoma - splenic marginal zone | Spleen |
2.0 |
0 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Leukocyte - Lymphocyte hyperplasia | Spleen |
10 |
6.0 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Leukocyte - Lymphocyte hyperplasia | Thymus |
2.1 |
0 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
6 - 6.1 |
6.0 |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 ⋅ Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Leukocyte - Myelocyte (Granulocyte) hyperplasia | Bone marrow |
54 |
73 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Leukocyte lymphoma | Leukocyte |
67 |
42 |
observed |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 ⋅ Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
|||
| Liver hepatocellular adenoma | Liver |
10 |
12 |
observed |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 ⋅ Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
|||
| Liver hepatocellular carcinoma | Liver |
0 |
2.0 |
observed |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 ⋅ Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
|||
| Liver neoplasm | Liver |
0 - 12 |
16 |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
||||
| Lung - Alveolus - Type II cell adenoma | Lung - Alveolus - Type II cell |
18 |
30 |
observed |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 ⋅ Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
|||
| Lung - Alveolus - Type II cell carcinoma | Lung - Alveolus - Type II cell |
4.1 |
2.0 |
observed |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 ⋅ Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
|||
| Lung neoplasm | Lung |
0 - 10 |
3 - 32 |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
||||
| Mammary gland neoplasm | Mammary gland |
0 |
0 |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
||||
| Ovary cyst | Ovary |
31 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
|||||
| Ovary cystadenoma | Ovary |
17 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
|||||
| Ovary neoplasm | Ovary |
17 |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
|||||
| Ovary tumor | Ovary |
observed |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
|||||
| Pancreas - Islet of Langerhans adenoma | Pancreas - Islet of Langerhans |
0 |
4.1 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Pancreas - Islet of Langerhans hyperplasia | Pancreas - Islet of Langerhans |
29 |
45 |
observed |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 ⋅ Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
|||
| Pancreas neoplasm | Pancreas |
0 |
4 |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
||||
| Pituitary gland - Pars distalis adenoma | Pituitary gland - Pars distalis |
2.1 |
2.1 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Pituitary gland - Pars distalis hyperplasia | Pituitary gland - Pars distalis |
11 |
4.2 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Pituitary gland cyst | Pituitary gland |
4.3 |
10 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Pituitary gland neoplasm | Pituitary gland |
0 - 2 |
0 - 2 |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
||||
| Prostate gland - Epithelial cell hyperplasia | Prostate gland - Epithelial cell |
8.3 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
|||||
| Stomach - Glandular cyst | Stomach - Glandular |
56 |
67 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Stomach - Glandular hyperplasia - mucosal | Stomach - Glandular |
17 |
16 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Thymus - Medulla hyperplasia | Thymus - Medulla |
0 |
6.1 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Thyroid gland - Follicular cell adenoma | Thyroid gland - Follicular cell |
6.25 |
2.0 |
observed |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 ⋅ Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
|||
| Thyroid gland - Follicular cell carcinoma | Thyroid gland - Follicular cell |
2.1 |
0 |
observed |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 ⋅ Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
|||
| Thyroid gland - Follicular cell hyperplasia | Thyroid gland - Follicular cell |
33 |
6.1 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Thyroid gland neoplasm | Thyroid gland |
8 |
2 |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
||||
| Tooth dysplasia | Bone - Nose |
2.0 |
12 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
||||
| Uterus - Endometrium - Stroma polyp | Uterus - Endometrium - Stroma |
4.1 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
|||||
| Uterus - Endometrium adenoma | Uterus - Endometrium |
2.0 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
|||||
| Uterus - Endometrium hyperplasia - cystic | Uterus - Endometrium |
47 |
References: Haines DC, Toxicol Pathol 2001 Nov-Dec;29(6):653-61 |
|||||
| Uterus - Endometrium tumor | Uterus - Endometrium |
observed |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
|||||
| Uterus neoplasm | Uterus |
8 |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
|||||
| (Unspecified organ) neoplasm | (Unspecified organ) |
42 |
25 - 60 |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
||||