Strain Summary[not specified]-Tg(Tyr-HRAS)60Lc Trp53^tm1Tyj

Strain Name	[not specified]-Tg(Tyr-HRAS)60Lc Trp53^tm1Tyj
Strain Type(s)	targeted mutation (knockout) • transgenic
Strain Synonym(s)	Tyr-H-RAS^V12G p53^-/- • Tyr-RAS p53 • Tyr-RAS p53^-/-
Description	Mice homozygous for a targeted mutation of Trp53 and transgenic for an activated human HRAS (G12V) oncogene under control of the melanocyte-specific mouse tyrosinase promoter. Genetic background was not specified.
Strain Genetics	List all models in MMHCdb carrying the Tg(Tyr-HRAS)60Lc allele Tg(Tyr-HRAS)60Lc
	List all models in MMHCdb carrying the Trp53^tm1Tyj allele Trp53^tm1Tyj / Trp53^tm1Tyj

Models
3 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Leukocyte - Lymphocyte lymphoma	Leukocyte - Lymphocyte			observed			References: Bardeesy N, Mol Cell Biol 2001 Mar;21(6):2144-53
Mesodermal cell/mesoblast sarcoma	Mesodermal cell/mesoblast			observed			References: Bardeesy N, Mol Cell Biol 2001 Mar;21(6):2144-53
Skin - Melanocyte melanoma	Skin - Melanocyte			26			References: Bardeesy N, Mol Cell Biol 2001 Mar;21(6):2144-53

Models