Strain SummaryFVB;129S-Tg(C3-1-TAg)cJeg Trp53tm1Tyj
Strain Name |
FVB;129S-Tg(C3-1-TAg)cJeg Trp53tm1Tyj |
Strain Type(s) |
targeted mutation (knockout) • transgenic |
Strain Synonym(s) |
C3(1)/TAG, p53-/- • FVB;129S-TgN(C3-1-TAg)cJeg Trp53tm1Tyj • C3(1)/TAg+/-;p53-/- • C3(1)/TAg;p53-/- • p53-/- TAG • p53-/- TAG SV129/FVB-N • TAG-/+, p53-/- |
Description |
Mice are hemizygous for the transgene and homozygous for the Trp53tm1Tyj allele. The genetic background of these mice is a mixture of FVB/N and 129S (a mixture of 129 substrains including 129S2/SvPas and probably 129S4/SvJae). |
Strain Genetics |
Tg(C3-1-TAg)cJeg |
| Trp53tm1Tyj / Trp53tm1Tyj |
| Frequency | ||||||||
|---|---|---|---|---|---|---|---|---|
| Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
| Leukocyte lymphoma | Leukocyte |
very high |
References: Maroulakou IG, Mol Carcinog 1997 Oct;20(2):168-74 |
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| Mammary gland carcinoma | Mammary gland |
observed |
References: Shibata MA, EMBO J 1999 May 17;18(10):2692-701 |
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