Strain SummarySTOCK Cdkn2atm1Rdp/+ Tg(MtTGFA)42Lmb Trp53tm1Tyj
Strain Name |
STOCK Cdkn2atm1Rdp/+ Tg(MtTGFA)42Lmb Trp53tm1Tyj |
Strain Type(s) |
targeted mutation (knockout) • transgenic |
Strain Synonym(s) |
B6;CD-1-Tg(MtTGFA)42Lmb Cdkn2atm1Rdp/+ Trp53tm1Tyj • B6;CD-1-TgN(MtTGFA)42Lmb Cdkn2atm1Rdp/+ Trp53tm1Tyj • MT-TGFα Ink4a/Arf+/- p53-/- • MT-TGFα Ink/Arf+/- p53-/- • MT42 Ink/Arf+/- p53-/- • MT42 Ink/Arf+/- p53-/- CD1/C57BL/6 • STOCK Tg(MtTGFA)42Lmb Cdkn2atm1Rdp/+ Trp53tm1Tyj |
Description |
Mice were heterozygous for mutant Cdkn2a, homozygous for mutant Trp53, and carried the Tg(MtTGFA)42Lmb transgene. This STOCK genetic background was a mixture predominantly of C57BL/6 and CD-1 and also included 129/Sv, 129S2/SvPas, and SJL. |
Strain Genetics |
Cdkn2atm1Rdp / Cdkn2a+ |
| Trp53tm1Tyj / Trp53tm1Tyj | |
| Tg(MtTGFA)42Lmb |
| Frequency | ||||||||
|---|---|---|---|---|---|---|---|---|
| Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
| Pancreas cystadenoma - serous | Pancreas |
30 |
References: Bardeesy N, Mol Cell Biol 2002 Jan;22(2):635-43 |
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| Pancreas metaplasia - tubular | Pancreas |
observed |
References: Bardeesy N, Mol Cell Biol 2002 Jan;22(2):635-43 |
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