Strain SummaryCD-1;129-Cdk4^tm1.1Bbd

Strain Name	CD-1;129-Cdk4^tm1.1Bbd
Strain Type(s)	targeted mutation (knock-in)
Strain Synonym(s)	Cdk4^R24C/R24C • mixed 129/SvJ X CD-1 Cdk4^R24C/R24C
Description	Homozygous mice. The genetic background of these mice was a mixture of 129X1/SvJ, 129S1/Sv, and outbred CD-1.
Strain Genetics	List all models in MMHCdb carrying the Cdk4^tm1.1Bbd allele Cdk4^tm1.1Bbd / Cdk4^tm1.1Bbd

Models
52 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Adipose tissue lipoma	Adipose tissue				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Adipose tissue liposarcoma	Adipose tissue				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Adrenal gland - Subcapsular cell lesion	Adrenal gland - Subcapsular cell				very low		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Blood vessel hemangiosarcoma	Blood vessel				22 - 56		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47 Sites of Metastasis: (Unspecified organ) , Intestine
Bone osteoma	Bone				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Bone osteosarcoma	Bone				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Connective tissue - Fibroblast fibrosarcoma	Connective tissue - Fibroblast				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Intestine tumor	Intestine				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Kidney tumor	Kidney				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Leukocyte - Lymphocyte hyperplasia	Spleen				6.0		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Leukocyte - Lymphocyte hyperplasia	Lymph node				13		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor	Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell				1.0 - 2.0		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Leukocyte - Myelocyte (Granulocyte) metaplasia	Leukocyte - Myelocyte (Granulocyte)				13		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Leukocyte lymphoma	Leukocyte				0 - 1.9		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Leukocyte lymphoma	Leukocyte	12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA)				20	References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7
Liver - Hepatocyte lesion	Liver - Hepatocyte				very low		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Liver hepatocellular adenoma	Liver			observed			References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Liver hepatocellular tumor	Liver		0	9.8 - 20			References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Lung adenocarcinoma	Lung				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Lung adenoma	Lung				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Lung tumor	Lung				18 - 32		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Mammary gland lesion	Mammary gland				very low		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Mesodermal cell/mesoblast sarcoma	Mesodermal cell/mesoblast				26 - 62		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Mesodermal cell/mesoblast sarcoma	Mesodermal cell/mesoblast	12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA)				observed	References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7
Mesodermal cell/mesoblast sarcoma - undifferentiated	Mesodermal cell/mesoblast				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Mesodermal cell/mesoblast tumor	Mesodermal cell/mesoblast				32 - 68		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Mesodermal cell/mesoblast tumor - benign	Mesodermal cell/mesoblast				6.0 - 7.6		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Ovary - Granulosa cell tumor	Ovary - Granulosa cell		observed				References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Pancreas - Islet of Langerhans - Beta cell tumor	Pancreas - Islet of Langerhans - Beta cell				30 - 42		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Pancreas - Islet of Langerhans adenoma	Pancreas - Islet of Langerhans				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Pancreas - Islet of Langerhans hyperplasia	Pancreas - Islet of Langerhans				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Pituitary gland adenocarcinoma	Pituitary gland				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Pituitary gland adenoma	Pituitary gland				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Pituitary gland tumor	Pituitary gland				6.0 - 22		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Prostate gland lesion	Prostate gland			very low			References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Salivary gland lesion	Salivary gland				very low		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Skin - Melanocyte melanoma	Skin - Melanocyte				0	0	References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47 ⋅ Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7
Skin - Melanocyte melanoma	Skin - Melanocyte	12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA)				70	References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7 7 pathology image(s)
Skin - Melanocyte melanoma	Skin - Melanocyte	ultraviolet-B radiation (UVB) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA)				observed	References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7
Skin - Melanocyte melanoma	Skin - Melanocyte	ultraviolet-B radiation (UVB)				0	References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7
Skin lesion	Skin	12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA)				very high	References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7 1 pathology image(s)
Skin lesion	Skin	7,12-dimethylbenz[a]anthracene (DMBA)				observed	References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7
Skin papilloma	Skin	12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA)				very high	References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7
Skin squamous cell carcinoma	Skin	12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA)				15	References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7
Testis - Leydig cell (Interstitial cell) hyperplasia	Testis - Leydig cell (Interstitial cell)			observed			References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Testis - Leydig cell (Interstitial cell) tumor	Testis - Leydig cell (Interstitial cell)			62 - 70			References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47 Sites of Metastasis: (Unspecified organ)
Thyroid gland tumor	Thyroid gland				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Uterus - Endometrium lesion	Uterus - Endometrium		very low				References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
(Unspecified organ) carcinoma	(Unspecified organ)	12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA)				observed	References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7
(Unspecified organ) histiocytoma - fibrous - malignant	(Unspecified organ)				observed		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
(Unspecified organ) lymphohematopoietic neoplasm	(Unspecified organ)				2.0 - 2.9		References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
(Unspecified organ) tumor	(Unspecified organ)		100	95			References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

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Description

Strain Genetics

Models