Strain Summary[not specified]-Cdk4^tm1.1Bbd Trp53^tm1Tyj

Strain Name	[not specified]-Cdk4^tm1.1Bbd Trp53^tm1Tyj
Strain Type(s)	targeted mutation (knock-in) • targeted mutation (knockout)
Strain Synonym(s)	Cdk4^R24C/R24C;p53^-/-
Description	Mice were homozgyous for both the Cdk4 and Trp53 mutant alleles. The genetic background of these mice was not specified, but it contained at least some 129X1/SvJ, some 129S1/Sv, some 129S2/SvPas, and some outbred CD-1.
Strain Genetics	List all models in MMHCdb carrying the Cdk4^tm1.1Bbd allele Cdk4^tm1.1Bbd / Cdk4^tm1.1Bbd
	List all models in MMHCdb carrying the Trp53^tm1Tyj allele Trp53^tm1Tyj / Trp53^tm1Tyj

Models
8 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Blood vessel hemangiosarcoma	Blood vessel					observed	References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Germ cell (sex not specified) teratoma	Germ cell (sex not specified)					9.8	References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Leukocyte - Lymphocyte - B-lymphocyte lymphoma - diffuse large cell (DLCL)	Spleen					observed	References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Leukocyte lymphoma	Leukocyte					51	References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Mesodermal cell/mesoblast sarcoma	Mesodermal cell/mesoblast					49	References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Muscle - Smooth leiomyosarcoma	Muscle - Smooth					observed	References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
Testis - Germ cell teratoma	Testis - Germ cell			observed			References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47
(Unspecified organ) tumor	(Unspecified organ)					100	References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Models