Strain SummaryB6.129S2-Trp53tm1Tyj/J

Strain Name

 B6.129S2-Trp53tm1Tyj/J

Strain Type(s)

 congenic  •  targeted mutation (knockout)

Strain Synonym(s)

 B6.129S2-Trp53tm1Tyj  •  B6.129S2-Trp53tm1Tyj  •  C57BL/6J-Trp53tm1Tyj  •  C57BL/6J-Trp53tm1Tyj  •  p53+/-  •  p53+/-  •  p53 heterozygous (+/-)  •  p53+/-  •  p53(+/-)

Description

 Heterozygous mice. The genetic background of these mice is congenic C57BL/6J.

Strain Links

 • JAX Mice

Strain Genetics

 Trp53tm1Tyj / Trp53+

Models

23 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Blood vessel hemangiosarcoma Subcutis

observed

References: Mikaelian I, Personal Communication 2004;():

7 pathology image(s)
CNS - Brain - Undifferentiated cell medulloblastoma CNS - Brain - Cerebellum

observed

References: Summers BA, Personal Communication 2004;():

10 pathology image(s)
CNS - Brain glioma CNS - Brain retrovirus expressing human PDGFB

100

References: Deng Q, Nat Commun 2019 Nov 7;10(1):5061

Esophagus hyperplasia Esophagus zinc-deficient

moderate

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Esophagus hyperplasia Esophagus

very low

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Esophagus tumor Esophagus N-nitrosomethylbenzylamine (NMBA)   ⋅   zinc-deficient

0

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Esophagus tumor Esophagus N-nitrosomethylbenzylamine (NMBA)

0

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach - Squamocolumnar junction with the glandular stomach tumor Forestomach - Squamocolumnar junction with the glandular stomach N-nitrosomethylbenzylamine (NMBA)   ⋅   zinc-deficient

88

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach - Squamocolumnar junction with the glandular stomach tumor Forestomach - Squamocolumnar junction with the glandular stomach N-nitrosomethylbenzylamine (NMBA)

19

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach hyperplasia Forestomach zinc-deficient

moderate

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach hyperplasia Forestomach

very low

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach squamous cell carcinoma Forestomach N-nitrosomethylbenzylamine (NMBA)   ⋅   zinc-deficient

13

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach tumor Forestomach N-nitrosomethylbenzylamine (NMBA)   ⋅   zinc-deficient

69

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach tumor Forestomach N-nitrosomethylbenzylamine (NMBA)

6.3

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Leukocyte - Lymphocyte lymphoma Leukocyte - Lymphocyte

0

References: Mukherjee M, PLoS One 2011;6(7):e22167

Leukocyte lymphoma Thymus zinc-deficient

10

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Leukocyte lymphoma Thymus

0

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Liver hepatocellular carcinoma Liver aflatoxin B1 (AFB1) (AFB1)

10

References: McGlynn KA, Cancer Res 2003 Aug 1;63(15):4594-601

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

0

References: Mukherjee M, PLoS One 2011;6(7):e22167

Mesodermal cell/mesoblast sarcoma - undifferentiated Subcutis

observed

References: Mikaelian I, Personal Communication 2004;():

11 pathology image(s)
Muscle - Striated - Skeletal rhabdomyosarcoma - poorly differentiated Muscle - Striated - Skeletal

observed

References: Mikaelian I, Personal Communication 2004;():

9 pathology image(s)
(Unspecified organ) carcinoma (Unspecified organ)

0

References: Mukherjee M, PLoS One 2011;6(7):e22167

(Unspecified organ) tumor (Unspecified organ)

52

References: Mukherjee M, PLoS One 2011;6(7):e22167