Strain SummaryVM.129-Trp53tm1Brd

Strain Name

 VM.129-Trp53tm1Brd

Strain Type(s)

 congenic  •  targeted mutation (knockout)

Strain Synonym(s)

 p53-deficient  •  p53 null (-/-)  •  VM (-/-)  •  VM.129(B6)-Trp53tm1Brd  •  VM congenic p53 null (-/-)

Description

 Homozygotes. This mutation had been backcrossed onto VM. The mutant allele was originally generated in "129/Sv" and had been crossed to C57BL/6 prior to the backcrossing.

Strain Genetics

 Trp53tm1Brd / Trp53tm1Brd

Models

11 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Blood vessel hemangiosarcoma Blood vessel

18

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Sites of Metastasis: Lymph node , Retroperitoneum
Bone osteosarcoma Bone

4.55

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

CNS - Brain - Astrocyte astrocytoma - anaplastic CNS - Brain - Astrocyte

0

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

CNS - Meninges meningioma CNS - Meninges

4.55

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Germ cell (sex not specified) teratoma Germ cell (sex not specified)

4.55

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Intestine - Large Intestine - Colon tumor Intestine - Large Intestine - Colon

0

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Intestine - Small Intestine tumor Intestine - Small Intestine

0

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Leukocyte lymphoma - non-Hodgkin Leukocyte

77

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

0

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

Prostate gland tumor Prostate gland

0

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22

(Unspecified organ) tumor - undifferentiated (Unspecified organ)

0

References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22