Strain SummaryB6.129S7-Trp53tm1Brd

Strain Name

 B6.129S7-Trp53tm1Brd

Strain Type(s)

 congenic  •  targeted mutation (knockout)

Strain Synonym(s)

 p53-/-  •  p53-/-  •  Trp53-/-  •  p53-/-

Description

 Homozygous mice. These mice have been backcrossed to C57BL/6. The mutation was generated on a 129S7/SvEvBrd-Hprt+ genetic background.

Strain Genetics

 Trp53tm1Brd / Trp53tm1Brd

Models

14 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Bone osteosarcoma Bone

0

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Bone osteosarcoma Bone jet-lag light cycle

observed

References: Lee S, PLoS One 2010;5(6):e10995

Connective tissue - Fibroblast fibrosarcoma Connective tissue - Fibroblast

3.2

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Leukocyte lymphoma Leukocyte

35 - 68

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Leukocyte lymphoma Thymus

32

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Leukocyte lymphoma Leukocyte jet-lag light cycle

observed

References: Lee S, PLoS One 2010;5(6):e10995

Liver hyperplasia Liver jet-lag light cycle

observed

References: Lee S, PLoS One 2010;5(6):e10995

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

16

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Mesodermal cell/mesoblast sarcoma - poorly differentiated Mesodermal cell/mesoblast

observed

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Mesodermal cell/mesoblast sarcoma - well differentiated Mesodermal cell/mesoblast

observed

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

Salivary gland hyperplasia Salivary gland jet-lag light cycle

observed

References: Lee S, PLoS One 2010;5(6):e10995

(Unspecified organ) angiosarcoma (Unspecified organ)

3.2

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

(Unspecified organ) histiocytoma - fibrous - malignant (Unspecified organ)

observed

References: Nister M, Oncogene 2005 May 19;24(22):3563-73

(Unspecified organ) tumor (Unspecified organ)

84 - 100

References: Nister M, Oncogene 2005 May 19;24(22):3563-73