Strain SummaryC57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs
Strain Name |
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs |
Strain Type(s) |
targeted mutation (knockout) |
Strain Synonym(s) |
C57Bl/6J-TgH(XPAIm)55Cmg x C57Bl/6J-TgH(p53Im)Δ26Cmg • Xpa-/-/p53+/- • XPA/p53 |
Description |
Compound mutant mice. The genetic background of these mice was predominantly C57BL/6J. This cohort was generated by crossing 2 mutant strains each congenic for C57BL/6J. |
Strain Genetics |
Xpatm1Hvs / Xpatm1Hvs |
| Trp53tm1Tyj / Trp53+ |
| Frequency | ||||||||
|---|---|---|---|---|---|---|---|---|
| Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
| Adipose tissue lipoma | Abdominal cavity |
0.8 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Adipose tissue lipoma | CNS - Brain |
6.7 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Adipose tissue lipoma | CNS - Brain | estradiol (E2) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Adrenal gland - Cortex adenoma | Adrenal gland - Cortex |
0 |
2.2 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla | diethylstilbestrol (DES) |
0 |
6.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Blood vessel hemangiosarcoma | Blood vessel |
0 |
1.5 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Bone lesion - fibro-osseous | Bone |
6.7 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Bone lesion - fibro-osseous | Bone | estradiol (E2) |
66.7 |
33.3 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Bone osteosarcoma | Bone |
0 - 0.8 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Bone osteosarcoma | Bone | diethylstilbestrol (DES) |
13.3 |
33.3 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Bone osteosarcoma | Bone | estradiol (E2) |
0 |
20 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| CNS - Brain glioma | CNS - Brain |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| CNS - Brain glioma | CNS - Brain | diethylstilbestrol (DES) |
0 |
6.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Connective tissue - Fibroblast fibrosarcoma | Skin |
0.8 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Connective tissue - Fibroblast fibrosarcoma | Uterus - Cervix |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||||
| Connective tissue - Fibroblast fibrosarcoma | Uterus - Cervix | diethylstilbestrol (DES) |
6.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Gallbladder papilloma | Gallbladder | 2-acetamidofluorene (2-AAF) |
13.3 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Intestine - Small Intestine tumor | Intestine - Small Intestine |
0 |
1.5 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Kidney adenoma | Kidney | phenacetin |
observed |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Kidney hyperplasia | Kidney | phenacetin |
observed |
observed |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Kidney transitional cell carcinoma | Kidney | p-cresidine |
6.7 |
13.3 - 20 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Kidney tumor | Kidney | phenacetin |
observed |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
0.8 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) | estradiol (E2) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Leukocyte - Myelocyte (Granulocyte) sarcoma - myeloid | Leukocyte - Myelocyte (Granulocyte) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Leukocyte lymphoma | Leukocyte |
0 - 2.3 |
0 - 13.3 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Leukocyte lymphoma | Leukocyte | Cyclosporin A |
40 - 50 |
13.3 - 72.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Leukocyte lymphoma | Leukocyte | diethylstilbestrol (DES) |
13.3 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Leukocyte lymphoma | Leukocyte | estradiol (E2) |
13.3 |
6.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Liver adenoma | Liver |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Liver hepatocellular carcinoma | Liver |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Liver hepatocellular carcinoma | Liver | estradiol (E2) |
0 |
6.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Liver tumor | Liver | p-cresidine |
13.3 |
80 - 93.3 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Liver tumor | Liver | 2-acetamidofluorene (2-AAF) |
26.7 |
6.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Lung adenoma | Lung |
2.3 - 6.7 |
0 - 0.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Lung adenoma | Lung | estradiol (E2) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Mammary gland adenocarcinoma | Mammary gland |
1.5 - 6.7 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Mammary gland adenocarcinoma | Mammary gland | diethylstilbestrol (DES) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Mesodermal cell/mesoblast sarcoma | CNS - Brain |
0.8 - 6.7 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Mesodermal cell/mesoblast sarcoma | Abdominal cavity |
0.8 - 6.7 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Mesodermal cell/mesoblast sarcoma | Skin |
46.7 |
40 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Mesodermal cell/mesoblast sarcoma | Skin | estradiol (E2) |
33.3 |
20 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Mesodermal cell/mesoblast sarcoma | CNS - Brain | estradiol (E2) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Mesodermal cell/mesoblast sarcoma | Abdominal cavity | estradiol (E2) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Muscle - Smooth leiomyosarcoma | Muscle - Smooth |
0.8 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Ovary - Germ cell teratoma | CNS - Brain |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||||
| Ovary - Germ cell teratoma | CNS - Brain | estradiol (E2) |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0.8 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||||
| Ovary adenoma - tubulostromal | Ovary |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||||
| Pituitary gland adenoma | Pituitary gland |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Pituitary gland adenoma | Pituitary gland | diethylstilbestrol (DES) |
13.3 |
13.3 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Placenta - Decidua deciduoma | Placenta - Decidua |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||||
| Testis - Germ cell teratoma | CNS - Brain |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||||
| Testis - Germ cell teratoma | CNS - Brain | estradiol (E2) |
6.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Testis - Leydig cell (Interstitial cell) adenoma | Testis - Leydig cell (Interstitial cell) |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||||
| Testis - Leydig cell (Interstitial cell) adenoma | Testis - Leydig cell (Interstitial cell) | diethylstilbestrol (DES) |
33.3 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Thymus thymoma | Thymus |
0.8 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Thyroid gland - Follicular cell adenoma | Thyroid gland - Follicular cell |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Urinary bladder tumor | Urinary bladder | p-cresidine |
13.3 |
40 - 46.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Urinary bladder tumor | Urinary bladder | 2-acetamidofluorene (2-AAF) |
60 |
53.3 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| (Unspecified organ) tumor | (Unspecified organ) |
0 - 12.9 |
0 - 9.0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| (Unspecified organ) tumor | (Unspecified organ) | p-cresidine |
26.7 |
80 - 93.3 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| (Unspecified organ) tumor | (Unspecified organ) | 2-acetamidofluorene (2-AAF) |
60 |
53.3 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| (Unspecified organ) tumor | (Unspecified organ) | diethylstilbestrol (DES) |
46.7 |
86.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||