Strain SummaryB6;129-Pappatm1Cac

Strain Name

 B6;129-Pappatm1Cac

Strain Type(s)

 targeted mutation (knockout)

Strain Synonym(s)

 Pappa-/-  •  PAPP-A KO

Description

 Homozygous mice. The genetic background of these mice was a mixture of C57BL/6 and "129Sv/E" (substrain not specified).

Strain Genetics

 Pappatm1Cac / Pappatm1Cac

Models

25 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Adrenal gland - Subcapsular cell hyperplasia Adrenal gland - Subcapsular cell

5.3 - 33

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Blood vessel tumor Blood vessel

3.3

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Kidney cyst Kidney

0

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Leukocyte - Lymphocyte hyperplasia Spleen

0 - 4.5

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Leukocyte lymphoma Leukocyte

0 - 14

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Sites of Metastasis: Kidney , Lung , Ovary , Pancreas , Spleen
Leukocyte tumor Leukocyte

33

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Liver hepatocellular carcinoma Liver

17

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Lung adenocarcinoma Lung

4.5 - 5.3

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Lung adenoma Lung

4.5 - 10.5

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Lung carcinoma Lung

23

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Lung hyperplasia Lung

0 - 4.5

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Mammary gland adenocarcinoma Mammary gland

0

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Ovary cyst - epithelial Ovary

9.1 - 10

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Pancreas - Islet of Langerhans hyperplasia Pancreas - Islet of Langerhans

0

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Peritoneum - Ovarian bursa cyst Peritoneum - Ovarian bursa

0 - 9.1

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Pituitary gland - Pars distalis hyperplasia - focal Pituitary gland - Pars distalis

0

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Pituitary gland adenoma Pituitary gland

0

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Testis - Leydig cell (Interstitial cell) hyperplasia Testis - Leydig cell (Interstitial cell)

0

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Thyroid gland - Follicular cell hyperplasia Thyroid gland - Follicular cell

0

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Thyroid gland cyst Thyroid gland

0

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Uterus - Endometrium - Stroma tumor Uterus - Endometrium - Stroma

0

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

Uterus - Endometrium hyperplasia - cystic Uterus - Endometrium

50 - 83

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9

(Unspecified organ) neoplasia (Unspecified organ)

high

References: Conover CA, J Gerontol A Biol Sci Med Sci 2010 Jun;65(6):590-9