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Strain SummaryB6;129S1-Pten^tm1Ppp/+

Strain Name	B6;129S1-Pten^tm1Ppp/+
Strain Type(s)	targeted mutation (knockout)
Strain Synonym(s)	B6,129-Pten^tm1Ppp/+ • Pten^+/- • Pten^+/-;Cdkn1b^+/+ • Pten^+/- • PTEN^+/-
Description	Heterozygous mice. The genetic background of this strain is a mixture of C57BL/6J and 129S1/Sv-p⁺ Tyr⁺ Kitl⁺.
Strain Genetics	List all models in MMHCdb carrying the Pten^tm1Ppp allele Pten^tm1Ppp / Pten⁺

Models
12 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Adrenal gland - Medulla tumor	Adrenal gland - Medulla					0 - 100	References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4
Intestine - Large Intestine - Colon adenocarcinoma - well-differentiated	Intestine - Large Intestine - Colon		observed	observed			References: Di Cristofano A, Nat Genet 1998 Aug;19(4):348-55
Intestine - Large Intestine adenocarcinoma	Intestine - Large Intestine					11	References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4
Intestine - Large Intestine hyperplasia - glandular	Intestine - Large Intestine		100	100			References: Di Cristofano A, Nat Genet 1998 Aug;19(4):348-55
Intestine - Large Intestine polyp	Intestine - Large Intestine		100	100			References: Di Cristofano A, Nat Genet 1998 Aug;19(4):348-55
Intestine - Small Intestine adenocarcinoma	Intestine - Small Intestine					23	References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4
Lung adenocarcinoma	Lung					5.7	References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4
Prostate gland hyperplasia	Prostate gland			100			References: Di Cristofano A, Nat Genet 1998 Aug;19(4):348-55
Prostate gland prostatic intraepithelial neoplasia (PIN)	Prostate gland			0 - observed		0 - 50	References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4 ⋅ Majumder PK, Proc Natl Acad Sci U S A 2003 Jun 24;100(13):7841-6
Skin - Epidermis hyperplasia	Skin - Epidermis		observed	observed			References: Di Cristofano A, Nat Genet 1998 Aug;19(4):348-55
Thyroid gland carcinoma - follicular	Thyroid gland					0 - 58	References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4
Uterus - Endometrium hyperplasia	Uterus - Endometrium		69				References: Di Cristofano A, Nat Genet 2001 Feb;27(2):222-4