Strain SummaryC57BL/6J +/+ : 129S1/Sv-Pten^tm1Ppp/+

Strain Name	C57BL/6J +/+ : 129S1/Sv-Pten^tm1Ppp/+
Strain Type(s)	chimeric • targeted mutation (knockout)
Description	Heterozygous targeted mutant (knockout) ES cells were injected into C57BL/6J blastocysts to generate these chimeric mice.
Strain Genetics	List all models in MMHCdb carrying the Pten^tm1Ppp allele Pten^tm1Ppp / Pten⁺
	Pten⁺ / Pten⁺

Models
9 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Intestine - Large Intestine - Colon adenocarcinoma - well-differentiated	Intestine - Large Intestine - Colon			observed			References: Di Cristofano A, Nat Genet 1998 Aug;19(4):348-55
Intestine - Large Intestine hyperplasia - glandular	Intestine - Large Intestine			100			References: Di Cristofano A, Nat Genet 1998 Aug;19(4):348-55
Intestine - Large Intestine polyp	Intestine - Large Intestine			100			References: Di Cristofano A, Nat Genet 1998 Aug;19(4):348-55
Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic	Leukocyte - Myelocyte (Granulocyte)			observed			References: Di Cristofano A, Nat Genet 1998 Aug;19(4):348-55
Prostate gland hyperplasia	Prostate gland			100			References: Di Cristofano A, Nat Genet 1998 Aug;19(4):348-55
Skin - Epidermis hyperplasia	Skin - Epidermis			observed			References: Di Cristofano A, Nat Genet 1998 Aug;19(4):348-55
Testis - Germ cell teratocarcinoma	Testis - Germ cell			observed			References: Di Cristofano A, Nat Genet 1998 Aug;19(4):348-55
Testis - Leydig cell (Interstitial cell) tumor	Testis - Leydig cell (Interstitial cell)			observed			References: Di Cristofano A, Nat Genet 1998 Aug;19(4):348-55
Thyroid gland adenocarcinoma - papillary	Thyroid gland			observed			References: Di Cristofano A, Nat Genet 1998 Aug;19(4):348-55

Models