Strain SummaryBALB/c-Il2rg^tm1Sug Rag^tm1Fwa Trp53^tm1Tyj

Strain Name	BALB/c-Il2rg^tm1Sug Rag^tm1Fwa Trp53^tm1Tyj
Strain Type(s)	targeted mutation (knockout)
Strain Synonym(s)	alymphocytic p53 knockout • BALB Rag2^-/-;Il2rg^-/- p53^-/- • RGKO-p53^-/-
Description	Compound mutant mice. The genetic background of these mice was predominantly BALB/c as they were generated by breeding strains fully backcrossed onto BALB/c and BALB/cJ. There was also likely some contribution from 129 [substrain not specified], 129S/SvEv-Gpi1^c, and/or 129S2/SvPas and possibly some C57BL/6. Female mice were homozygous for the Il2rg mutant allele while male mice were hemizygous (X-linked).
Strain Genetics	List all models in MMHCdb carrying the Trp53^tm1Tyj allele Trp53^tm1Tyj / Trp53^tm1Tyj
	List all models in MMHCdb carrying the Rag2^tm1Fwa allele Rag2^tm1Fwa / Rag2^tm1Fwa
	List all models in MMHCdb carrying the Il2rg^tm1Sug allele Il2rg^tm1Sug / Il2rg^tm1Sug
	List all models in MMHCdb carrying the Il2rg^tm1Sug allele Il2rg^tm1Sug

Models
19 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Blood vessel hemangiosarcoma	Blood vessel		86	68	65 - 76		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Blood vessel hemangiosarcoma	Skin				observed		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Blood vessel hemangiosarcoma	Muscle				observed		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Blood vessel hemangiosarcoma	Liver				observed		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Blood vessel hemangiosarcoma	Lung				observed		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Blood vessel hemangiosarcoma	Peritoneum				observed		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Blood vessel hemangiosarcoma	Intestine				observed		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Blood vessel hemangiosarcoma	Spleen				observed		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Blood vessel hemangiosarcoma	Urogenital tract (sex not specified)				observed		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Bone osteosarcoma	Bone		0	0	0		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Leukocyte lymphoma	Thymus				observed		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Leukocyte lymphoma	Leukocyte		14	12	13		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Lung carcinoma	Lung				observed		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Mammary gland carcinoma	Mammary gland		9.5	4.0	observed - 6.5		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Mesodermal cell/mesoblast sarcoma	Mesodermal cell/mesoblast				82		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Pericyte hemangiopericytoma	Limb - Forelimb				observed		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
(Unspecified organ) carcinoma	(Unspecified organ)				34		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
(Unspecified organ) sarcoma	(Unspecified organ)		14	12	13		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
(Unspecified organ) tumor	(Unspecified organ)		29	32	100		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38

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Description

Strain Genetics

Models