Strain SummaryBALB/c-Il2rg^tm1Sug Rag^tm1Fwa Trp53^tm1Tyj/+

Strain Name	BALB/c-Il2rg^tm1Sug Rag^tm1Fwa Trp53^tm1Tyj/+
Strain Type(s)	targeted mutation (knockout)
Strain Synonym(s)	BALB Rag2^-/-;Il2rg^-/- p53^+/- • RGKO-p53^+/-
Description	Compound mutant mice. The genetic background of these mice was predominantly BALB/c as they were generated by breeding strains fully backcrossed onto BALB/c and BALB/cJ. There was also likely some contribution from 129 [substrain not specified], 129S/SvEv-Gpi1^c, and/or 129S2/SvPas and possibly some C57BL/6. Female mice were homozygous for the Il2rg mutant allele while male mice were hemizygous (X-linked).
Strain Genetics	List all models in MMHCdb carrying the Trp53^tm1Tyj allele Trp53^tm1Tyj / Trp53⁺
	List all models in MMHCdb carrying the Rag2^tm1Fwa allele Rag2^tm1Fwa / Rag2^tm1Fwa
	List all models in MMHCdb carrying the Il2rg^tm1Sug allele Il2rg^tm1Sug / Il2rg^tm1Sug
	List all models in MMHCdb carrying the Il2rg^tm1Sug allele Il2rg^tm1Sug

Models
7 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Blood vessel hemangiosarcoma	Blood vessel		12.5	29	19		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Bone osteosarcoma	Limb				observed		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Bone osteosarcoma	Bone		19	7.3	14		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38 Sites of Metastasis: Lung
Leukocyte lymphoma	Leukocyte		3.1	4.9	3.8		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
Mammary gland carcinoma	Mammary gland		52	9.8	35		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
(Unspecified organ) sarcoma	(Unspecified organ)		1.6	4.9	2.9		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38
(Unspecified organ) tumor	(Unspecified organ)		37.5	61	100		References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38

Models