Reference SummaryAyanga B, Genes Chromosomes Cancer 2006 Jul;45(7):668-75

Title

 Genetic mapping of a putative tumor suppressor locus that influences tumorigenesis and metastasis in mice.

Authors

 Ayanga B; Price R; Gu X; Lozano G; Evans SC

Journal

 Genes Chromosomes Cancer

Volume

 45

Issue

 7

Year

 2006

Pages

 668-75

Abstract

 The tumor suppressor TP53 is mutated in approximately 70% of Li-Fraumeni syndrome (LFS) families; however, other genes may lead to the predisposition to tumors in other families. We developed a mouse model to search for other tumor suppressors that may be involved in the syndrome. Inbred CE/J mice, which succumb to multiple types of tumors similar to those found in LFS, were crossed with the Trp53-null 129-Trp53tm1Tyj mouse. We monitored the tumor onset and type and found a significant earlier tumor onset in the CE/J:129-Trp53tm1Tyj mice compared with 129-Trp53tm1Tyj mice with a Trp53-null allele. Additionally, in CE/J:129-Trp53tm1Tyj-Trp53+/- mice, the tumors metastasize, which does not occur in other strains of mice. Using simple-sequence length polymorphism analysis for loss of heterozygosity in tumors, we identified a putative tumor suppressor locus within 1 cM on mouse chromosome 11, which encompasses 12 mapped genes.

Links

 J:108788 – MGI References
16586494 – National Library of Medicine/PubMed
Visual Summary Grid

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
CE129F2-Trp53tm1Tyj Blood vessel hemangioma Blood vessel

1.9
CE129F2-Trp53tm1Tyj/+ Blood vessel hemangioma Blood vessel

4.2
CE129F2-Trp53tm1Tyj Blood vessel hemangiosarcoma Blood vessel

22
CE129F2-Trp53tm1Tyj/+ Blood vessel hemangiosarcoma Blood vessel

7.0
CE129F2-Trp53tm1Tyj/+ Bone osteosarcoma Bone

11
CE129F2-Trp53tm1Tyj Connective tissue - Fibroblast fibrosarcoma Connective tissue - Fibroblast

7.4
CE129F2-Trp53tm1Tyj/+ Connective tissue - Fibroblast fibrosarcoma Connective tissue - Fibroblast

7.0
CE129F2-Trp53tm1Tyj/+ Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell

1.4
CE129F2-Trp53tm1Tyj/+ Leukocyte - Myelocyte (Granulocyte) leukemia Leukocyte - Myelocyte (Granulocyte)

1.4
CE129F2-Trp53tm1Tyj Leukocyte lymphoma Leukocyte

63
CE129F2-Trp53tm1Tyj Leukocyte lymphoma Thymus

52
CE129F2-Trp53tm1Tyj/+ Leukocyte lymphoma Leukocyte

14
CE129F2-Trp53tm1Tyj/+ Liver hepatoma Liver

13
CE129F2-Trp53tm1Tyj/+ Lung carcinoma Lung

1.4
CE129F2-Trp53tm1Tyj/+ Mammary gland carcinoma Mammary gland

1.4
CE129F2-Trp53tm1Tyj Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

31
CE129F2-Trp53tm1Tyj/+ Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

32
CE129F2-Trp53tm1Tyj/+ Muscle - Smooth leiomyosarcoma Muscle - Smooth

1.4
CE129F2-Trp53tm1Tyj Muscle - Striated - Skeletal rhabdomyosarcoma Muscle - Striated - Skeletal

1.9
CE129F2-Trp53tm1Tyj/+ Muscle - Striated - Skeletal rhabdomyosarcoma Muscle - Striated - Skeletal

2.8
CE129F2-Trp53tm1Tyj/+ Ovary carcinoma Ovary

1.4
CE129F2-Trp53tm1Tyj Ovary hyperplasia Ovary

3.7
CE129F2-Trp53tm1Tyj/+ Ovary hyperplasia Ovary

7.0
CE129F2-Trp53tm1Tyj/+ Preputial gland (male) hyperplasia Preputial gland (male)

observed
CE129F2-Trp53tm1Tyj/+ Sertoli cell (sex not specified) tumor Sertoli cell (sex not specified)

1.4
CE129F2-Trp53tm1Tyj/+ Uterus - Endometrium hyperplasia Uterus - Endometrium

31
CE129F2-Trp53tm1Tyj/+ (Unspecified organ) adenocarcinoma - cystic (Unspecified organ)

1.4
CE129F2-Trp53tm1Tyj/+ (Unspecified organ) adenoma (Unspecified organ)

9.9
CE129F2-Trp53tm1Tyj/+ (Unspecified organ) cyst (Unspecified organ)

8.5
CE129F2-Trp53tm1Tyj/+ (Unspecified organ) squamous cell carcinoma (Unspecified organ)

1.4
CE/J (Unspecified organ) tumor (Unspecified organ)

33
129-Trp53tm1Tyj/J (Unspecified organ) tumor (Unspecified organ)

57
129-Trp53tm1Tyj/J (Unspecified organ) tumor (Unspecified organ)

100
CE129F2-Trp53tm1Tyj (Unspecified organ) tumor (Unspecified organ)

98
CE129F1-Trp53tm1Tyj/+ (Unspecified organ) tumor (Unspecified organ)

100
CE129F2-Trp53tm1Tyj/+ (Unspecified organ) tumor (Unspecified organ)

100