Reference Summaryvan Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22
Title |
Genetic background influences timing, morphology and dissemination of lymphomas in p53-deficient mice. | ||||||||||
Authors |
van Meyel DJ; Sanchez-Sweatman OH; Kerkvliet N; Stitt L; Ramsay DA; Khokha R; Chambers AF; Cairncross JG | ||||||||||
Journal |
Int J Oncol | ||||||||||
Volume |
13 | ||||||||||
Issue |
5 | ||||||||||
Year |
1998 | ||||||||||
Pages |
917-22 | ||||||||||
Abstract |
To examine the influence of genetic background on tumorigenesis in p53- deficient mice, we used selective breeding to produce congenic mice with a null p53 gene mutation introduced into the VM inbred strain. Cohorts of homozygous p53 null (-/-) mice from the original C57B6/129Sv mixed strain and the VM congenic strain were monitored for spontaneous tumor development, as were control cohorts of wild-type (+/+) and heterozygous (+/-) animals. Twenty-six of 28 C57B6/129Sv (-/-) mice died by the study end date (median survival =184.5 days). Twenty-three of 26 VM (-/-) mice died and their survival was significantly shorter (111 days, P<0.0001). Of 26 C57B6/129Sv (-/-) mice that died, 21 were autopsied: all 21 had lymphomas. Of 26 VM mice that died (23 -/-, 3 +/- ), 21 were autopsied: 19 developed lymphoma and two had sarcomas. Several mice had additional neoplasms. Lymphomas in VM mice were distinct from those in C57B6/129Sv mice in that they i) arose on average more than two months earlier, ii) involved thymus more often than spleen or lymph nodes and iii) were more often poorly differentiated, high grade tumors. These results demonstrate that genetic background alone influences the onset, morphology and dissemination of lymphomas in p53-deficient mice and suggest the presence of genes which modify the timing and biological nature of lymphomas in these mice. | ||||||||||
Links |
J:51144 – MGI References 9772279 – National Library of Medicine/PubMed |
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Strain Notes
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| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| B6;129-Trp53tm1Brd | Blood vessel hemangiosarcoma | Blood vessel |
4.35 |
||
| VM.129-Trp53tm1Brd/+ | Blood vessel hemangiosarcoma | Blood vessel |
0 |
||
| VM.129-Trp53tm1Brd | Blood vessel hemangiosarcoma | Blood vessel |
18 |
||
| B6;129-Trp53tm1Brd | Bone osteosarcoma | Bone |
0 |
||
| VM.129-Trp53tm1Brd/+ | Bone osteosarcoma | Bone |
0 |
||
| VM.129-Trp53tm1Brd | Bone osteosarcoma | Bone |
4.55 |
||
| B6;129-Trp53tm1Brd | CNS - Brain - Astrocyte astrocytoma - anaplastic | CNS - Brain - Astrocyte |
4.35 |
||
| VM.129-Trp53tm1Brd/+ | CNS - Brain - Astrocyte astrocytoma - anaplastic | CNS - Brain - Astrocyte |
0 |
||
| VM.129-Trp53tm1Brd | CNS - Brain - Astrocyte astrocytoma - anaplastic | CNS - Brain - Astrocyte |
0 |
||
| B6;129-Trp53tm1Brd | CNS - Meninges meningioma | CNS - Meninges |
0 |
||
| VM.129-Trp53tm1Brd/+ | CNS - Meninges meningioma | CNS - Meninges |
0 |
||
| VM.129-Trp53tm1Brd | CNS - Meninges meningioma | CNS - Meninges |
4.55 |
||
| B6;129-Trp53tm1Brd | Germ cell (sex not specified) teratoma | Germ cell (sex not specified) |
0 |
||
| VM.129-Trp53tm1Brd/+ | Germ cell (sex not specified) teratoma | Germ cell (sex not specified) |
0 |
||
| VM.129-Trp53tm1Brd | Germ cell (sex not specified) teratoma | Germ cell (sex not specified) |
4.55 |
||
| B6;129-Trp53tm1Brd | Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon |
0 |
||
| VM.129-Trp53tm1Brd/+ | Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon |
0 |
||
| VM.129-Trp53tm1Brd | Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon |
0 |
||
| B6;129-Trp53tm1Brd | Intestine - Small Intestine tumor | Intestine - Small Intestine |
0 |
||
| VM.129-Trp53tm1Brd/+ | Intestine - Small Intestine tumor | Intestine - Small Intestine |
0 |
||
| VM.129-Trp53tm1Brd | Intestine - Small Intestine tumor | Intestine - Small Intestine |
0 |
||
| B6;129-Trp53tm1Brd | Leukocyte lymphoma - non-Hodgkin | Leukocyte |
91 |
||
| B6;129-Trp53tm1Brd | Leukocyte lymphoma - non-Hodgkin | Thymus |
26 |
||
| B6;129-Trp53tm1Brd | Leukocyte lymphoma - non-Hodgkin | Spleen |
52 |
||
| B6;129-Trp53tm1Brd | Leukocyte lymphoma - non-Hodgkin | Lymph node |
13 |
||
| VM.129-Trp53tm1Brd/+ | Leukocyte lymphoma - non-Hodgkin | Leukocyte |
12.5 |
||
| VM.129-Trp53tm1Brd | Leukocyte lymphoma - non-Hodgkin | Leukocyte |
77 |
||
| VM.129-Trp53tm1Brd/? | Leukocyte lymphoma - non-Hodgkin | Leukocyte |
50 |
||
| VM.129-Trp53tm1Brd/? | Leukocyte lymphoma - non-Hodgkin | Thymus |
39 |
||
| VM.129-Trp53tm1Brd/? | Leukocyte lymphoma - non-Hodgkin | Spleen |
11 |
||
| B6;129-Trp53tm1Brd | Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast |
8.7 |
||
| VM.129-Trp53tm1Brd/+ | Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast |
0 |
||
| VM.129-Trp53tm1Brd | Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast |
0 |
||
| B6;129-Trp53tm1Brd | Prostate gland tumor | Prostate gland |
0 |
||
| VM.129-Trp53tm1Brd/+ | Prostate gland tumor | Prostate gland |
0 |
||
| VM.129-Trp53tm1Brd | Prostate gland tumor | Prostate gland |
0 |
||
| B6;129-Trp53tm1Brd | (Unspecified organ) tumor - undifferentiated | (Unspecified organ) |
4.35 |
||
| VM.129-Trp53tm1Brd/+ | (Unspecified organ) tumor - undifferentiated | (Unspecified organ) |
0 |
||
| VM.129-Trp53tm1Brd | (Unspecified organ) tumor - undifferentiated | (Unspecified organ) |
0 |