Reference SummaryNaigamwalla D, Cancer Res 2000 Dec 15;60(24):6856-8

Title

Polyethylene glycol 8000 and colon carcinogenesis: inhibition in the F344 rat, promotion in the Min mouse.

Authors

Naigamwalla D; Chia MC; Tran TT; Medline A; Hay K; Gallinger S; Bruce WR

Journal

Cancer Res

Volume

Issue

Year

2000

Pages

6856-8

Abstract

It has recently been reported that 5% polyethylene glycol 8000 (PEG 8000; Mr 8000) in the diet markedly inhibits the development of colonic tumors in carcinogen-treated rats. To assess the possible use of this agent as a preventive or treatment agent for patients with familial adenomatous polyposis, we determined the effect of PEG 8000 on spontaneous carcinogenesis in the Min mouse. PEG at a 5% concentration in the diet of Min mice did not affect the number of small intestinal or cecal tumors but did increase the number of colon tumors and the number of animals with colonic tumors (2 of 18 versus 12 of 22 animals; P < 0.001). Although the chemopreventive effect of PEG 8000 in rats is remarkable, we suggest a cautious approach in long-term testing of PEG as a chemopreventive agent for subjects at risk for colonic neoplasia.

Links

J:66914 – MGI References
11156379 – National Library of Medicine/PubMed

Strain Notes

Strain	Note
B6;129P2-Apc^Min/+	Mice were generated by mating C57BL/6J-Apc^Min/+ males with Msh2^tm1Mak/+ females, then intercrossing offspring.
B6;129P2-Apc^Min/+ Msh2^tm1Mak/+	Mice were generated by mating C57BL/6J-Apc^Min/+ males with Msh2^tm1Mak/+ females, then intercrossing offspring.
SWR/Hsd	Purchased from Harlan Sprague-Dawley, Inc at 6 weeks of age.

Models
Strain	Model Name	Treatment Agent(s)	Organ Affected	Frequency
B6;129P2-Apc^Min/+	Intestine - Large Intestine - Cecum tumor		Intestine - Large Intestine - Cecum	0 - observed
B6;129P2-Apc^Min/+	Intestine - Large Intestine - Cecum tumor	polyethylene glycol 8000 (PEG 8000)	Intestine - Large Intestine - Cecum	observed
B6;129P2-Apc^Min/+ Msh2^tm1Mak/+	Intestine - Large Intestine - Cecum tumor		Intestine - Large Intestine - Cecum	observed
B6;129P2-Apc^Min/+ Msh2^tm1Mak/+	Intestine - Large Intestine - Cecum tumor	polyethylene glycol 8000 (PEG 8000)	Intestine - Large Intestine - Cecum	0 - observed
B6;129P2-Apc^Min/+	Intestine - Large Intestine - Colon adenoma		Intestine - Large Intestine - Colon	0 - 29
B6;129P2-Apc^Min/+	Intestine - Large Intestine - Colon adenoma	polyethylene glycol 8000 (PEG 8000)	Intestine - Large Intestine - Colon	17 - 75
B6;129P2-Apc^Min/+ Msh2^tm1Mak/+	Intestine - Large Intestine - Colon adenoma		Intestine - Large Intestine - Colon	0
B6;129P2-Apc^Min/+ Msh2^tm1Mak/+	Intestine - Large Intestine - Colon adenoma	polyethylene glycol 8000 (PEG 8000)	Intestine - Large Intestine - Colon	0 - 71
SWR/Hsd	Intestine - Large Intestine - Colon foci - aberrant crypt (ACF)	azoxymethane (AOM)	Intestine - Large Intestine - Colon	observed
SWR/Hsd	Intestine - Large Intestine - Colon foci - aberrant crypt (ACF)	azoxymethane (AOM) polyethylene glycol 8000 (PEG 8000)	Intestine - Large Intestine - Colon	observed
SWR/Hsd	Intestine - Large Intestine - Colon polyp - adenomatous	azoxymethane (AOM)	Intestine - Large Intestine - Colon	0
SWR/Hsd	Intestine - Large Intestine - Colon polyp - adenomatous	azoxymethane (AOM) polyethylene glycol 8000 (PEG 8000)	Intestine - Large Intestine - Colon	observed
B6;129P2-Apc^Min/+	Intestine - Small Intestine adenoma		Intestine - Small Intestine	observed
B6;129P2-Apc^Min/+	Intestine - Small Intestine adenoma	polyethylene glycol 8000 (PEG 8000)	Intestine - Small Intestine	observed
B6;129P2-Apc^Min/+ Msh2^tm1Mak/+	Intestine - Small Intestine adenoma		Intestine - Small Intestine	observed
B6;129P2-Apc^Min/+ Msh2^tm1Mak/+	Intestine - Small Intestine adenoma	polyethylene glycol 8000 (PEG 8000)	Intestine - Small Intestine	observed